Conductance oscillations in strongly correlated fractional quantum Hall line junctions

We present a detailed theory of transport through line junctions formed by counterpropagating single-branch fractional-quantum-Hall edge channels having different filling factors. Intriguing transport properties are exhibited when strong Coulomb interactions between electrons from the two edges are present. Such strongly correlated line junctions can be classified according to the value of an effective line-junction filling factor n that is the inverse of an even integer. Interactions turn out to affect transport most importantly for n=1/2 and n=1/4. A particularly interesting case is n=1/4 corresponding to, e.g., a junction of edge channels having filling factor 1 and 1/5, respectively. We predict its differential tunneling conductance to oscillate as a function of voltage. This behavior directly reflects the existence of novel Majorana-fermion quasiparticle excitations in this type of line junction. Experimental accessibility of such systems in current cleaved-edge overgrown samples enables direct testing of our theoretical predictions.Comment: 2 figures, 10 pages, RevTex4, v2: added second figure for clarit

Voedselcriminaliteit

ARTIKELEN: 1. K.E. Gussow en L.H. Kuiper - De bestrijding van voedselfraude in Nederland 2. S. van Ruth en W. Huisman - Kwetsbaarheid voor voedselfraude in de vleessector 3. D. Siegel en D.P. van Uhm - Zwarte kaviaar; over criminele netwerken, illegale handel en de bedreiging van de steur 4. Ch.I. Sambrook - Illegale pesticiden en voedselcriminaliteit 5. J.A. van den Akker en E.M.R. de Lange - Naar een Europese aanpak van voedselfraude 6. Ch. Vansteenkiste en T. Schotte - De rol van Europol in de strijd tegen voedselcriminaliteit 7. Internetsites. SAMENVATTING: Nederland en andere Europese landen zijn in de afgelopen periode opgeschrikt door verschillende voedselschandalen. Vooral in de vleessector is van alles mis, zoveel is duidelijk na de ontdekking van de paardenvleesfraude in 2013. In dit themanummer wordt het verband verkend tussen voedsel(on)veiligheid en criminaliteit, waarbij aansluiting wordt gezocht met criminologische theorieën over gelegenheidsstructuren, motivaties en organisatiecriminaliteit

Studies on vibration characteristics of a pear using finite element method

The variation of the vibration characteristics of a Huanghua pear was investigated using finite element simulations. A new image processing technique was used to obtain the unsymmetrical and un-spherical geometrical model of a pear. The vibration characteristics of this type of pear with the correlation of its behavior with geometrical configurations and material characteristics were investigated using numerical modal analysis. The results showed that the eigenfrequency increased with the increasing pear Young’s modulus, while decreased with increasing pear density, and decreased with increasing pear volume. The results of this study provided foundation for further investigations of the physical characteristics of fruits and vegetables by using finite element simulations

Tuning Heme Functionality: The Cases of Cytochrome c Oxidase and Myoglobin Oxidation

The (Fe-O) moiety of Cytochrome c oxidase ferryl intermediate of the dioxygen activation reaction and the oxy-myoglobin (Mb-O2) structure have been probed by QM/MM (hybrid quantum mechanical/ molecular mechanical) calculations using Density Functional Theory (DFT)/MM to elucidate the effect of the heme propionates and the protein matrix on the chemistry of heme Fe-O moieties. On this line, we have probed the role of His97 in various protonation states of the heme propionate-6 in Mb and compared the results to that of the Cytochrome c oxidase chemistry

Tumor infiltrating lymphocytes (TIL) therapy in metastatic melanoma: boosting of neoantigen-specific T cell reactivity and long-term follow-up

Treatment of metastatic melanoma with autologous tumor infiltrating lymphocytes (TILs) is currently applied in several centers. Robust and remarkably consistent overall response rates, of around 50% of treated patients, have been observed across hospitals, including a substantial fraction of durable, complete responses. Purpose Execute a phase I/II feasibility study with TIL therapy in metastatic melanoma at the Netherlands Cancer Institute, with the goal to assess feasibility and potential value of a randomized phase III trial. Experimental Ten patients were treated with TIL therapy. Infusion products and peripheral blood samples were phenotypically characterized and neoantigen reactivity was assessed. Here, we present long-term clinical outcome and translational data on neoantigen reactivity of the T cell products. Results Five out of 10 patients, who were all anti-PD-1 naive at time of treatment, showed an objective clinical response, including two patients with a complete response that are both ongoing for more than 7 years. Immune monitoring demonstrated that neoantigen-specific T cells were detectable in TIL infusion products from three out of three patients analyzed. For six out of the nine neoantigen-specific T cell responses detected in these TIL products, T cell response magnitude increased significantly in the peripheral blood compartment after therapy, and neoantigen-specific T cells were detectable for up to 3 years after TIL infusion. Conclusion The clinical results from this study confirm the robustness of TIL therapy in metastatic melanoma and the potential role of neoantigen-specific T cell reactivity. In addition, the data from this study supported the rationale to initiate an ongoing multicenter phase III TIL trial.Surgical oncolog